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The 2024 Vanderbilt finding that a diastolic BP increase greater than 17 mmHg during late phase 2 of the Valsalva maneuver identifies patients with high sympathetic nerve activity is a simpler, office-based alternative to plasma catecholamine testing

Mild nausea, constipation, or changes in digestion may occur early on and usually improve as the body adjusts

Therefore primary ovarian granular cells were further selected for in vitro experimentation